Publications

SELECTED PUBLICATIONS

  1. Coppola I, Brouwers B, Walker L, Alar C, Meulemans S, White A, Ramos-Molina, B. (CA), Creemers JWM. 2022. Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice. Mol Metab. doi: 10.1016/j.molmet.2022.101627.


  2. Nuñez-Sanchez MA, Martinez-Sanchez MA, Verdejo-Sanchez M, Garcia-Ibañez P, Oliva-Bolarin A, Ramos-Molina, B. (CA), Moreno DA, Ruiz-Alcaraz AJ. 2022. Anti-Leukemic Activity of Brassica-Derived Bioactive Compounds in HL-60 Myeloid Leukemia Cells. Int J Mol Sci. doi: 10.3390/ijms232113400.


  3. Kuchay MS, Martínez-Montoro JI, Llamoza-Torres CJ, Fernández-García JC, Ramos-Molina, B. (CA). 2022. Liver cirrhosis and sarcopenia: a dreadful combination. Hepatobiliary Surg Nutr. doi: 10.21037/hbsn-22-355. PMID: 36268240.


  4. Fernández-García JC, Barrios-Rodríguez R, Asenjo-Plaza M, Ramos-Molina, B., Molina-Vega M, Guzmán-Guzmán A, Moreno-León L, Yubero-Serrano EM, Rius-Díaz F, Valdés S, Martínez-González MÁ, Jiménez-Moleón JJ, Tinahones FJ. 2022. Metformin, testosterone, or both in men with obesity and low testosterone: A double-blind, parallel-group, randomized controlled trial. Metabolism. doi: 10.1016/j.metabol.2022.155290. PMID: 35985506.


  5. Núñez-Sánchez MA, Melgar S, O'Donoghue K, Martínez-Sánchez MA, Fernández-Ruiz VE, Ferrer-Gómez M, Ruiz-Alcaraz AJ, Ramos-Molina, B. (CA). 2022. Crohn’s Disease, Host-Microbiota Interactions, and Immunonutrition: Dietary Strategies Targeting Gut Microbiome as Novel Therapeutic Approaches. Int J Mol Sci. doi: 10.3390/ijms23158361. PMID: 35955491.


  6. Kuchay MS, Martínez-Montoro JI, Kaur P, Fernández-García JC,Ramos-Molina, B. (CA). 2022. Non-alcoholic fatty liver disease-related fibrosis and sarcopenia: An altered liver-muscle crosstalk leading to increased mortality risk. Ageing Res Rev. doi: 10.1016/j.arr.2022.10169. PMID: 35843589.


  7. Martínez-Sánchez MA, Núñez-Sánchez MÁ, Balaguer-Román A, Oliva-Bolarín A, Pujante-Gilabert G, Hernández-Agüera Q, Mesa-López MJ, Egea-Valenzuela J, Queipo-Ortuño MI, Ruiz-Alcaraz AJ, Ferrer-Gómez M, Gil-Martínez J, Ramos-Molina, B. (CA). 2022. Gut Microbiome Modification through Dietary Intervention in Patients with Colorectal Cancer: Protocol for a Prospective, Interventional, Controlled, Randomized Clinical Trial in Patients with Scheduled Surgical Intervention for CRC. J Clin Med. doi: 10.3390/jcm11133613. PMID: 35806897.


  8. Martínez-Montoro JI, Martínez-Sánchez MA, Balaguer-Román A, Gil-Martínez J, Mesa- López MJ, Egea-Valenzuela J, Ruiz-Alcaraz AJ, Queipo-Ortuño MI, Ferrer M, Fernández- García JC, Ramos-Molina, B. (CA). 2022. Dietary modulation of gut microbiota in patients with colorectal cancer undergoing surgery: A review. Int J Surg. doi: 10.1016/j.ijsu.2022.106751. PMID: 35803517.


  9. Socol CT, Chira A, Martinez-Sanchez MA, Nuñez-Sanchez MA, Maerescu CM, Mierlita D, Rusu AV, Ruiz-Alcaraz AJ, Trif M, Ramos-Molina, B. (CA). 2022. Leptin Signaling in Obesity and Colorectal Cancer. Int J Mol Sci. doi: 10.3390/ijms23094713. PMID: 35563103.


  10. Ruiz-Alcaraz AJ, Martínez-Sánchez MA, García-Peñarrubia P, Martinez-Esparza M, Ramos-Molina, B., Moreno DA. 2022. Analysis of the anti-inflammatory potential of Brassica bioactive compounds in a human macrophage-like cell model derived from HL-60 cells. Biomed Pharmacother. doi: 10.1016/j.biopha.2022.112804. PMID: 35279599.


  11. Hliwa, A.; Mika, A.; Sledzinski, M.; Laski, D.; Ramos-Molina, B.; Sledzinski, T. 2022. Changes in the Serum Fatty Acid Profile After Anhepatic Phase of Orthotopic Liver Transplantation Procedure. Frontiers of Physiology. doi: 10.3389/fphys.2022.817987. PMID: 35422709.


  12. Kuchay, M.S.; Martinez-Montoro, J.I.; Choudhary, N.; Fernandez-Garcia, J.C.; Ramos-Molina, B. (CA). 2021. Non-alcoholic Fatty Liver Disease in Lean and Non-Obese Individuals: Current and Future Challenges. Biomedicines. doi: 10.3390/biomedicines9101346. PMID: 34680463.


  13. Castellano-Castillo, D.; Ramos-Molina, B.; Oliva-Olivera, W.; Ocaña-Wilhelmi, L.; Queipo-Ortuño, M.I.; Cardona, F. 2021. Genome Profiling H3K4Me3 Histone Modification in Human Adipose Tissue During Obesity and Insulin Resistance. Biomedicines. doi: 10.3390/biomedicines9101363. PMID: 34680480.


  14. Martinez-Montoro, J.I.; Kuchay, M.S.; Balaguer-Roman, A.; Martinez-Sanchez, M.A.; Frutos, M.D.; Fernandez-Garcia, J.C.; Ramos-Molina, B. (CA). 2021. Gut Microbiota and Related Metabolites in the Pathogenesis of Non-Alcoholic Steatohepatitis and its Resolution after Bariatric Surgery. Obesity Reviews. doi: 10.1111/obr.13367. PMID: 34729904.


  15. Sanchez-Alcoholado, L.; Laborda-Illanes, A.; Otero, A.; Ordoñez, R.; Gonzalez-Gonzalez, A.; Plaza-Andrades, I.; Ramos-Molina, B.; Gomez-Millan, J.; Queipo-Ortuño, M.I. 2021. Relationships of gut microbiota composition, short-chain fatty acids and polyamines with the pathological response to neoadjuvant radiochemotherapy in colorectal cancer patients. Int J Mol Sci. doi: 10.3390/ijms22179549. PMID: 34502456.


  16. Hliwa, A.; Ramos-Molina, B.; Laski, D.; Mika, A.; Sledzinski, T. 2021. The Role of Fatty Acids in Non-Alcoholic Fatty Liver Disease Progression: An Update. Int J Mol Sci. 2021 Jun 27;22(13):6900. doi: 10.3390/ijms22136900. PMID: 34199035.


  17. Aerts, L.; Terry, N.A.; Sainath, N.N.; Torres, C.; Martín, M.G.; Ramos-Molina, B. (CA); Creemers, J.W. 2021. Novel Homozygous Inactivating Mutation in the PCSK1 Gene in an Infant with Congenital Malabsorptive Diarrhea. 2021. Genes (Basel). 2021 May 10;12(5):710. doi: 10.3390/genes12050710. PMID: 34068683


  18. Coppola, I.; Brouwers, B.; Meulemans, S.; Ramos-Molina, B. (CA); Creemers, J.W.M. Differential Effects of Furin Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic B Cells of Mice. 2021. Int J Mol Sci. 2021 Jun 14;22(12):6344. doi: 10.3390/ijms22126344. PMID: 34198511.


  19. Brouwers, B.; Coppola, I.; Vints, K.; et al; Ramos-Molina, B. (CA); Creemers, J.W. 2021. Loss of Furin in β cells induces an mTORC1-ATF4 anabolic pathway that leads to β cell dysfunction. Diabetes. 2020 Dec 4:db200474. doi: 10.2337/db20-0474. PMID: 33277337.


  20. Vohl, M.C.; Malagon, M.M.; Ramos-Molina, B. (CA). 2020. Editorial: Dietary Factors, Epigenetics and their Implications for Human Obesity. Front Endocrinol (Lausanne). 2020 Aug 28;11:601. doi: 10.3389/fendo.2020.00601. PMID: 32982984.


  21. Fernandez-Garcia, J.C.; Martinez-Sanchez, M.A.; Muñoz-Garach A.; et al; Ramos-Molina, B. (CA) 2020. Effect of a lifestyle intervention program with energy-restricted Mediterranean diet and exercise on the serum polyamine metabolome in individuals at high cardiovascular risk: a randomized clinical trial. Am J Clin Nutr. 2020 Apr 4:nqaa064. doi: 10.1093/ajcn/nqaa064. PMID: 32246717.


  22. Castellano-Castillo, D.; Ramos-Molina, B. (CFA); Cardona, F.; Queipo-Ortuño, M.I. 2020. Epigenetic regulation of white adipose tissue in the onset of obesity and metabolic diseases Obes Rev. 2020 Nov; 21(11):e13054. doi: 10.1111/obr.13054. PMID: 32542987.


  23. Ocaña-Wilhelmi, L.; Cardona, F.; Garrido-Sanchez, L.; Fernandez-Garcia, D.; Tinahones, F.J.; Ramos-Molina, B. 2020. Change in serum polyamine metabolome pattern after bariatric surgery in obese patients with metabolic syndrome. Surg Obes Relat Dis. 2020 Feb;16(2):306-311. doi: 10.1016/j.soard.2019.10.024. PMID: 31813775.


  24. Sanchez-Alcoholado, L.; Ordoñez, R.; Otero, A.; et al; Ramos-Molina, B.; Queipo-Ortuño, M.I. 2020. Gut Microbiota-Mediated Inflammation and Gut Permeability in Patients with Obesity and Colorectal Cancer. Int J Mol Sci. 2020 Sep 16;21(18):6782. doi: 10.3390/ijms21186782. PMID: 32947866.


  25. Molina-Vega, M.; Castellano-Castillo, D.; Sanchez-Alcoholado, L.; et al; Ramos-Molina, B.; Tinahones, F.J. 2020. Relationship of Zonulin with Serum PCSK9 Levels after a High Fat Load in a Population of Obese Subjects Biomolecules. 2020 May 11;10(5):748. doi: 10.3390/biom10050748. PMID: 32403394.


  26. Sánchez-Alcoholado, L.; Ramos-Molina, B. (CFA); Otero, A.; Laborda-Illanes, A.; Ordoñez, R.; Medina, J.A.; Gómez-Millán, J.; Queipo-Ortuño, M.I. 2020. The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response. Cancers (Basel). 2020 May 29;12(6):1406. doi: 10.3390/cancers12061406. PMID: 32486066.


  27. Castellano-Castillo, D; Moreno-Indias, I; Sanchez-Alcoholado, L; et al; Ramos-Molina, B; Cardona, F. 2019. Altered Adipose Tissue DNA Methylation Status in Metabolic Syndrome: Relationships Between Global DNA Methylation and Specific Methylation at Adipogenic, Lipid Metabolism and Inflammatory Candidate Genes and Metabolic Variables. J Clin Med. 2019 Jan 13;8(1):87. doi: 10.3390/jcm8010087. PMID: 30642114.


  28. Ramos-Molina, B. (CA); Queipo-Ortuño, M.I.; Lambertos, A.; Tinahones, F.J.; Peñafiel, R. 2019. Dietary ang Gut Microbiota Polyamines in Obesity- and Age-Related Diseases. Front Nutr. 2019 Mar 14;6:24. doi: 10.3389/fnut.2019.00024. eCollection 2019. PMID: 30923709.


  29. Samarra, I.; Ramos-Molina, B.; Queipo-Ortuño, M.I.; Tinahones, F.J.; Aro, L.; Del Pino-Rius, A.; Herrero, P.; Canela, N. 2019. Gender-Related Differences on Polyamine Metabolome in Liquid Biopsies by a Simple and Sensitive Two-Step Liquid-Liquid Extraction and LC-MS/MS. Biomolecules. 2019 Nov 26;9(12):779. doi: 10.3390/biom9120779. PMID: 31779105.


  30. Ramos-Molina, B. (CA); Sanchez-Alcoholado, L.; Cabrera-Mulero, A.; Lopez-Dominguez, R.; Carmona-Saez, P.; Garcia-Fuentes, E.; Moreno-Indias, I.; Tinahones, F.J. 2019. Gut Microbiota Composition is Associated with the Global DNA Methylation Pattern in Obesity. Front Genet. 2019 Jul 3;10:613. doi: 10.3389/fgene.2019.00613. PMID: 31333715.


  31. Clemente-Postigo, M.; Oliva-Olivera, W.; Coin-Araguez, L.; et al; Ramos-Molina, B.; Tinahones, F.J. 2019. Metabolic endotoxemia promotes adipose dysfunction and inflammation in human obesity. Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E319-E332. doi: 10.1152/ajpendo.00277.2018. PMID: 30422702.


  32. Fernandez-Garcia, JC; DelPino-Rius, A; Samarra, I; et al; Ramos-Molina, B (CA); Tinahones, FJ. 2019. Type 2 Diabetes is Associated with a Different Pattern of Serum Polyamines: a Case-Control Study from the PREDIMED-Plus Trial. J Clin Med. 2019 Jan 10;8(1):71. doi: 10.3390/jcm8010071. PMID: 30634588.


  33. Ramos-Molina, B.; Castellano-Castillo, D.; Pastor, O.; Ocaña-Wilhelmi, L.; Fernandez-García, D.; Romero-Gomez, M.; Cardona, F.; Tinahones, F.J. 2018. A pilot study of serum sphingomyelin dynamics in subjects with severe obesity and non-alcoholic steatohepatitis after sleeve gastrectomy. Obes Surg. 2019 Mar;29(3):983-989. doi: 10.1007/s11695-018-3612-2. PMID: 30488259.


  34. Palau-Rodriguez, M.; Tulipani, S.; Marco-Ramell, A.; et al; Ramos-Molina, B.; Andres-Lacueva, C. 2018. Characterization of metabolomic profile associated with metabolic improvement after bariatric surgery in subjects with morbid obesity. J Proteome Res. 2018 Aug 3;17(8):2704-2714. doi: 10.1021/acs.jproteome.8b00144. PMID: 29893570.


  35. Ramos-Molina, B.; Castellano-Castillo, D.; Alcaide-Torres, J.; et al; Tinahones, F.J. 2018. Differential effects of restrictive and malabsorptive bariatric surgery procedures on the serum lipidome in obese subjects. J Clin Lipidol. 2018 Nov-Dec;12(6):1502-1512. doi: 10.1016/j.jacl.2018.07.006. PMID: 30143432.


  36. Ramos-Molina, B.; Molina-Vega, M.; Fernandez-Garcia, J.C.; Creemers, J.W.C.. 2018. Hyperphagia and Obesity in Prader-Willi Syndrome: PCSK1 Deficiency and Beyond? Genes (Basel). 2018 Jun 7;9(6):288. doi: 10.3390/genes9060288. PMID: 29880780.


  37. Palau-Rodriguez, M.; Tulipani, S.; Marco-Ramell, A.; et al; Ramos-Molina, B.; Andres-Lacueva, C. 2018. Metabotypes of response to bariatric surgery independent of the magnitude of weight loss. PLoS One. 2018 Jun 1;13(6):e0198214. doi: 10.1371/journal.pone.0198214. PMID: 29856816.


  38. de Faudeur, G.; Brouwers, B.; Schuit, F.; Creemers, J.W.M.; Ramos-Molina, B. 2018. Transgenic Artifacts Caused by Passenger Human Growth Hormone. Trends Endocrinol Metab. 2018 Oct;29(10):670-674. doi: 10.1016/j.tem.2018.05.005. PMID: 29921469.


  39. Winters, A.; Ramos-Molina, B. (CFA); Jarvela, T.S.; Yerges-Armstrong, L.; Pollin, T.; Lindberg, I. 2017. Functional analysis of PCSK2 coding variants: a founder effect in the Old Order Amish population. Diabetes Res Clin Pract. 2017 Sep;131:82-90. doi: 10.1016/j.diabres.2017.06.023. PMID: 28719828.


  40. Stijnen, P.; Brouwers, B.; Dirkx, E.; et al; Ramos-Molina, B.; Creemers, J.W. 2016. Endoplasmic reticulum-associated degradation of the mouse PC1/3-N222D hypomorph and human PCSK1 mutations contributes to obesity. Int J Obes (Lond). 2016 Jun;40(6):973-81. doi: 10.1038/ijo.2016.3. PMID: 26786350.


  41. Ramos-Molina, B.; Martin, M.G.; Lindberg, I. 2016. PCSK1 Variants and Human Obesity. Prog Mol Biol Transl Sci. 2016;140:47-74. doi: 10.1016/bs.pmbts.2015.12.001. PMID: 27288825.


  42. Yamamoto, H.; Ramos-Molina, B. (CFA); Lick, A.N.; Prideaux, M.; Albornoz, V.; Bonewald, L.; Lindberg, I. 2016. Posttranslational processing of FGF23 in osteocytes during the osteoblast to osteocyte transition. Bone. 2016 Mar;84:120-130. doi: 10.1016/j.bone.2015.12.055. PMID: 26746780.


  43. Stijnen, P.; Ramos-Molina, B. (CFA); O'Rahilly, S.; Creemers, J.W. 2016. PCSK1 mutations and human endocrinopathies: from obesity to gastrointestinal disorders. Endocr Rev. 2016 Aug;37(4):347-71. doi: 10.1210/er.2015-1117. PMID: 27187081.


  44. Ramos-Molina, B; Lick, AN; Nasrolahi Shirazi, A; Oh, D; Tiwari, R; El-Sayed, NS; Parang, K; Lindberg, I. 2015. Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors. PLoS One. 2015 Jun 25;10(6):e0130417. doi: 10.1371/journal.pone.0130417. PMID: 26110264.


  45. Ramos-Molina, B.; Lick, A.N.; Blanco, E.H.; Posada-Salgado, J.A.; Martinez-Mayorga, K.; Johnson, A.T.; Jiao, G.-S.; Lindberg, I. 2015. Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays. Biochem Pharmacol. 2015 Jul 15;96(2):107-18. doi: 10.1016/j.bcp.2015.05.008. PMID: 26003844.


  46. Ramos-Molina, B.; Lindberg, I. 2015. Phosphorylation and alternative splicing of 7B2 reduce prohormone convertase 2 activation. Mol Endocrinol. 2015 May; 29(5):756-64. doi: 10.1210/me.2014-1394. PMID: 25811241.


  47. Blanco, E.H.; Ramos-Molina, B.; Lindberg, I. 2015. Revisiting PC1/3 mutants: Dominant-negative effect of endoplasmic reticulum-retained mutants. Blanco EH, Ramos-Molina B, Lindberg I. Endocrinology. 2015 Oct;156(10):3625-37. doi: 10.1210/en.2015-1068. PMID: 26207343.


CA: Corresponding Author.
CFA: Co-First Author.